{"id":21336,"date":"2026-06-05T13:50:13","date_gmt":"2026-06-05T13:50:13","guid":{"rendered":"https:\/\/akdenizolay.com.tr\/index.php\/2026\/06\/05\/yeni-tedavi-yasam-suresini-yaklasik-iki-katina-cikarabilir\/"},"modified":"2026-06-05T13:50:14","modified_gmt":"2026-06-05T13:50:14","slug":"yeni-tedavi-yasam-suresini-yaklasik-iki-katina-cikarabilir","status":"publish","type":"post","link":"https:\/\/akdenizolay.com.tr\/index.php\/2026\/06\/05\/yeni-tedavi-yasam-suresini-yaklasik-iki-katina-cikarabilir\/","title":{"rendered":"Yeni tedavi, ya\u015fam s\u00fcresini yakla\u015f\u0131k iki kat\u0131na \u00e7\u0131karabilir"},"content":{"rendered":"

Pankreas kanseri, en zor tedavi edilen kanser t\u00fcrleri aras\u0131nda yer al\u0131yor. Bu nedenle bilim d\u00fcnyas\u0131 uzun y\u0131llard\u0131r daha etkili tedavi se\u00e7enekleri geli\u015ftirmek i\u00e7in \u00e7al\u0131\u015f\u0131yor. Son d\u00f6nemde a\u00e7\u0131klanan ara\u015ft\u0131rma sonu\u00e7lar\u0131n\u0131n \u00f6nemli bir geli\u015fmeye i\u015faret etti\u011fini dile getiren Anadolu Sa\u011fl\u0131k Merkezi Hastanesi\u2019nden T\u0131bbi Onkoloji Uzman\u0131 Prof. Dr. Ye\u015fim Y\u0131ld\u0131r\u0131m, \u201cYap\u0131lan g\u00fcncel bir ara\u015ft\u0131rmada hedefe y\u00f6nelik yeni bir tedavinin standart kemoterapiye k\u0131yasla ya\u015fam s\u00fcresini yakla\u015f\u0131k iki kat art\u0131rd\u0131\u011f\u0131 ve \u00f6l\u00fcm riskini y\u00fczde 60 oran\u0131nda azaltt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc\u201d a\u00e7\u0131klamas\u0131nda bulundu.\u00a0<\/strong><\/p>\n

29 May\u0131s-2 Haziran 2026 tarihleri aras\u0131nda Chicago’da d\u00fczenlenen Amerikan Klinik Onkoloji Derne\u011fi (ASCO) Y\u0131ll\u0131k Kongresi’nde payla\u015f\u0131lan \u00e7al\u0131\u015fmada, KRAS ve benzeri RAS mutasyonlar\u0131n\u0131 hedefleyen daraxonrasib adl\u0131 yeni ila\u00e7 standart kemoterapi ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131. Ara\u015ft\u0131rmaya daha \u00f6nce en az bir tedavi alm\u0131\u015f yakla\u015f\u0131k 500 metastatik pankreas kanseri hastas\u0131n\u0131n dahil edildi\u011fini aktaran Anadolu Sa\u011fl\u0131k Merkezi Hastanesi\u2019nden T\u0131bbi Onkoloji Uzman\u0131 Prof. Dr. Ye\u015fim Y\u0131ld\u0131r\u0131m, \u201cDaraxonrasib kullanan hastalarda ortalama ya\u015fam s\u00fcresi 13,2 aya ula\u015f\u0131rken, kemoterapi alanlarda bu s\u00fcre 6,7 ay olarak \u00f6l\u00e7\u00fcld\u00fc. Ayr\u0131ca yeni tedavinin \u00f6l\u00fcm riskini yakla\u015f\u0131k y\u00fczde 60 azaltt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc\u201d dedi.<\/p>\n

KRAS mutasyonuna kar\u015f\u0131 ilk g\u00fc\u00e7l\u00fc sonu\u00e7lar elde edildi<\/strong><\/p>\n

Bu \u00e7al\u0131\u015fmay\u0131 \u00f6nemli k\u0131lan noktan\u0131n, pankreas kanserinin temel nedenlerinden biri olarak kabul edilen KRAS mutasyonuna kar\u015f\u0131 ilk kez bu kadar g\u00fc\u00e7l\u00fc sonu\u00e7lar elde edilmesi oldu\u011funu vurgulayan Y\u0131ld\u0131r\u0131m, \u201cPankreas kanserlerinin y\u00fczde 90\u2019\u0131ndan fazlas\u0131nda g\u00f6r\u00fclen RAS mutasyonlar\u0131, y\u0131llard\u0131r bilim insanlar\u0131n\u0131n hedefinde olmas\u0131na ra\u011fmen etkili \u015fekilde kontrol alt\u0131na al\u0131nam\u0131yordu. \u00c7\u00fcnk\u00fc bu mutasyonlar\u0131n yap\u0131s\u0131 nedeniyle uzun y\u0131llar boyunca \u2018hedeflenemez\u2019 oldu\u011fu d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu. RASolute 302 \u00e7al\u0131\u015fmas\u0131nda de\u011ferlendirilen daraxonrasib ise t\u00fcm RAS mutasyonlar\u0131n\u0131 hedefleyebilen ilk ila\u00e7lardan biri olarak \u00f6ne \u00e7\u0131k\u0131yor. Bu yeni ila\u00e7, kanser h\u00fccrelerinin b\u00fcy\u00fcme sinyallerini bask\u0131lamay\u0131 ama\u00e7l\u0131yor\u201d dedi.<\/p>\n

Y\u0131ld\u0131r\u0131m s\u00f6zlerine, \u201cMetastatik pankreas kanserinde ilk kez bir RAS inhibit\u00f6r\u00fcn\u00fcn faz 3 \u00e7al\u0131\u015fmada sa\u011fkal\u0131m avantaj\u0131 g\u00f6stermesi nedeniyle elde edilen sonu\u00e7lar, pankreas kanseri tedavisinde yeni bir d\u00f6nemin ba\u015flang\u0131c\u0131 olarak de\u011ferlendiriliyor\u201d \u015feklinde devam etti.<\/p>\n

Tedavi planlamas\u0131nda genetik testlerin rol\u00fc art\u0131yor<\/strong><\/p>\n

Bu geli\u015fmenin t\u00fcm hastalar i\u00e7in kesin bir \u00e7\u00f6z\u00fcm anlam\u0131na gelmedi\u011fini de s\u00f6zlerine ekleyen Y\u0131ld\u0131r\u0131m, \u201cAncak \u00f6zellikle belirli genetik \u00f6zelliklere sahip pankreas kanseri hastalar\u0131 i\u00e7in daha etkili ve ki\u015fiselle\u015ftirilmi\u015f tedavilerin \u00f6n\u00fcn\u00fc a\u00e7abilece\u011fini d\u00fc\u015f\u00fcn\u00fcyoruz. Ayr\u0131ca bu bulgular, kanser tedavisinde genetik testlerin \u00f6nemini de bir kez daha ortaya koyuyor\u201d bilgisini verdi.<\/p>\n

\u00a0<\/p>\n

Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":"

Pankreas kanseri, en zor tedavi edilen kanser t\u00fcrleri aras\u0131nda yer al\u0131yor.<\/p>\n","protected":false},"author":1,"featured_media":21337,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-21336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/21336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=21336"}],"version-history":[{"count":1,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/21336\/revisions"}],"predecessor-version":[{"id":21338,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/21336\/revisions\/21338"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media\/21337"}],"wp:attachment":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=21336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=21336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=21336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}