\u00dcsk\u00fcdar \u00dcniversitesi NP\u0130STANBUL Hastanesi N\u00f6roloji Uzman\u0131 Dr. Celal \u015eal\u00e7ini, ALS tedavisinde geli\u015ftirilen yeni ila\u00e7lar, yenilik\u00e7i tedavi yakla\u015f\u0131mlar\u0131 ve multidisipliner rehabilitasyon uygulamalar\u0131n\u0131n hastalar\u0131n ya\u015fam s\u00fcresi ile ya\u015fam kalitesini iyile\u015ftirmedeki rol\u00fc hakk\u0131nda a\u00e7\u0131klamalarda bulundu.<\/p>\n
ALS tedavisinde geli\u015ftirilen yeni ila\u00e7lar, hastal\u0131\u011f\u0131n ilerlemesini yava\u015flatma potansiyeli ta\u015f\u0131yor!<\/strong><\/p>\n ALS tedavisinde son y\u0131llarda semptomatik y\u00f6netimden hastal\u0131\u011f\u0131n ilerlemesini yava\u015flatmay\u0131 hedefleyen tedavilere do\u011fru \u00f6nemli bir kayma ya\u015fand\u0131\u011f\u0131n\u0131 ifade eden Dr. Celal \u015eal\u00e7ini, \u201cG\u00fcn\u00fcm\u00fczde FDA onayl\u0131 d\u00f6rt ila\u00e7 bulunuyor. Baz\u0131 ila\u00e7lar hastal\u0131\u011f\u0131n ilerlemesini yava\u015flat\u0131rken baz\u0131lar\u0131 pseudobulbar (yutma gibi) etkiyi y\u00f6netiyor.\u201d dedi.<\/p>\n \u00d6zellikle SOD1 gen mutasyonuna ba\u011fl\u0131 ALS i\u00e7in onaylanan baz\u0131 ila\u00e7lar\u0131n n\u00f6rodejenerasyon (h\u00fccre y\u0131k\u0131m\u0131) belirte\u00e7lerini azaltabildi\u011fini aktaran Dr. \u015eal\u00e7ini, \u201cBaz\u0131 hastalarda da fonksiyonel iyile\u015fme potansiyeli sunarak umut vaat ediyor. Bu geli\u015fmeler, hastal\u0131\u011f\u0131n genetik ve molek\u00fcler mekanizmalar\u0131n\u0131n daha iyi anla\u015f\u0131lmas\u0131yla h\u0131zlan\u0131yor.\u201d \u015feklinde konu\u015ftu.<\/p>\n ALS hastalar\u0131n\u0131n tedavi s\u00fcrecindeki zorluklar, multidisipliner bir yakla\u015f\u0131mla hafifletilebilir!<\/strong><\/p>\n ALS hastalar\u0131n\u0131n tedavi s\u00fcrecindeki zorluklar\u0131n, multidisipliner bir yakla\u015f\u0131mla hafifletilebilece\u011fine i\u015faret eden Dr. \u015eal\u00e7ini, \u015funlar\u0131 s\u00f6yledi:<\/p>\n \u201cSolunum y\u00f6netimi i\u00e7in noninvaziv ventilasyon (NIV) ve \u00f6ks\u00fcr\u00fck destek cihazlar\u0131, ileti\u015fim i\u00e7in yard\u0131mc\u0131 ileti\u015fim cihazlar\u0131 (AAC) kritik \u00f6neme sahiptir. Kas kramplar\u0131, spastisite ve a\u011fr\u0131, ila\u00e7lar ve fizik tedavi ile y\u00f6netilirken, yutma g\u00fc\u00e7l\u00fc\u011f\u00fc ve beslenme sorunlar\u0131 diyetisyen rehberli\u011fi ve PEG t\u00fcp\u00fc (kar\u0131ndan t\u00fcp ile beslenme) ile ele al\u0131n\u0131r. Ayr\u0131ca, hastalar\u0131n ve bak\u0131c\u0131lar\u0131n psikolojik ve duygusal ihtiya\u00e7lar\u0131 i\u00e7in destek gruplar\u0131 ve dan\u0131\u015fmanl\u0131k hizmetleri hayati rol oynar.\u201d<\/p>\n N\u00f6romod\u00fclasyon, gen ve k\u00f6k h\u00fccre tedavileri ALS i\u00e7in umut vadediyor!<\/strong><\/p>\n \u0130leri tedavi se\u00e7enekleri aras\u0131nda n\u00f6romod\u00fclasyon teknikleri, gen terapileri ve k\u00f6k h\u00fccre tedavilerinin b\u00fcy\u00fck potansiyel ta\u015f\u0131d\u0131\u011f\u0131na dikkat \u00e7eken Dr. \u015eal\u00e7ini, \u201cOdaklanm\u0131\u015f ultrason (TPS) ve Pathmaker’\u0131n MyoRegulator cihaz\u0131 gibi n\u00f6romod\u00fclasyon yakla\u015f\u0131mlar\u0131, sinir h\u00fccrelerindeki hipereksitabiliteyi azaltmay\u0131 ve motor fonksiyonu iyile\u015ftirmeyi hedefleyen klinik \u00e7al\u0131\u015fmalarda de\u011ferlendirilir.\u201d dedi.<\/p>\n Gen terapilerinin, \u00f6zellikle antisens oligon\u00fckleotitler (ASO’lar) ve RNA interferans\u0131 (RNAi), SOD1, FUS ve Ataxin-2 gibi gen mutasyonlar\u0131n\u0131 hedefleyerek toksik protein \u00fcretimini engellemeyi ama\u00e7lad\u0131\u011f\u0131na da de\u011finen Dr. \u015eal\u00e7ini, \u201cK\u00f6k h\u00fccre tedavileri, \u00f6zellikle mezenkimal k\u00f6k h\u00fccreler (MKH’ler), n\u00f6ronlara trofik destek sa\u011flamak, ba\u011f\u0131\u015f\u0131kl\u0131k sistemini mod\u00fcle etmek ve hasarl\u0131 n\u00f6ronlar\u0131 potansiyel olarak de\u011fi\u015ftirmek i\u00e7in ara\u015ft\u0131r\u0131l\u0131yor.\u201d diye konu\u015ftu.<\/p>\n ALS hastalar\u0131nda hareketlili\u011fi koruman\u0131n anahtar\u0131 fizyoterapi ve rehabilitasyon!<\/strong><\/p>\n Fizyoterapi ve rehabilitasyon programlar\u0131n\u0131n, ALS hastalar\u0131n\u0131n hareketlili\u011fini korumak ve ba\u011f\u0131ms\u0131zl\u0131klar\u0131n\u0131 art\u0131rmak i\u00e7in hayati \u00f6neme sahip oldu\u011funu vurgulayan Dr. Celal \u015eal\u00e7ini, s\u00f6zlerini \u015f\u00f6yle tamamlad\u0131:<\/p>\n \u201cGerme ve eklem hareket a\u00e7\u0131kl\u0131\u011f\u0131 egzersizleri kontrakt\u00fcrleri \u00f6nlerken, d\u00fc\u015f\u00fck yo\u011funluklu kuvvet antrenmanlar\u0131 kas k\u00fctlesini korumaya yard\u0131mc\u0131 olur. Spastisite ve a\u011fr\u0131 y\u00f6netimi i\u00e7in pasif germe, \u0131s\u0131 terapisi ve su egzersizleri gibi y\u00f6ntemler kullan\u0131l\u0131r. Yard\u0131mc\u0131 cihazlar (baston, y\u00fcr\u00fcte\u00e7, tekerlekli sandalye) ve ev adaptasyonlar\u0131, hastalar\u0131n g\u00fcvenli\u011fini ve hareketlili\u011fini destekler.\u201d<\/p>\n \u00a0<\/p>\n \u00a0<\/p>\n Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":" \u00dcsk\u00fcdar \u00dcniversitesi NP\u0130STANBUL Hastanesi N\u00f6roloji Uzman\u0131 Dr.<\/p>\n","protected":false},"author":1,"featured_media":25888,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-25887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/25887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=25887"}],"version-history":[{"count":1,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/25887\/revisions"}],"predecessor-version":[{"id":25889,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/25887\/revisions\/25889"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media\/25888"}],"wp:attachment":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=25887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=25887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=25887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}