{"id":34357,"date":"2026-09-17T14:18:24","date_gmt":"2026-09-17T11:18:24","guid":{"rendered":"https:\/\/akdenizolay.com.tr\/index.php\/2026\/09\/17\/hpvden-obeziteye-sigaradan-genetik-yatkinliga\/"},"modified":"2026-09-17T14:18:25","modified_gmt":"2026-09-17T11:18:25","slug":"hpvden-obeziteye-sigaradan-genetik-yatkinliga","status":"publish","type":"post","link":"https:\/\/akdenizolay.com.tr\/index.php\/2026\/09\/17\/hpvden-obeziteye-sigaradan-genetik-yatkinliga\/","title":{"rendered":"HPV\u2019den obeziteye, sigaradan genetik yatk\u0131nl\u0131\u011fa"},"content":{"rendered":"<p> Kad\u0131n \u00fcreme organlar\u0131n\u0131 etkileyen kanserler jinekolojik kanser olarak tan\u0131mlan\u0131yor. \u00a0Rahim, yumurtal\u0131k, rahim a\u011fz\u0131, vulva ve vajen kanserleri en yayg\u0131n g\u00f6r\u00fclen jinekolojik kanserleri olu\u015fturuyor. D\u00fcnyada her y\u0131l yakla\u015f\u0131k 1,5 milyon kad\u0131na jinekolojik kanser tan\u0131s\u0131 konulurken, yakla\u015f\u0131k 700 bin kad\u0131n bu hastal\u0131k nedeniyle ya\u015fam\u0131n\u0131 yitiriyor. \u00dclkemizde de her y\u0131l yakla\u015f\u0131k 15 bin kad\u0131nda jinekolojik kanser te\u015fhis ediliyor.\u00a0<strong>Ac\u0131badem Ata\u015fehir Hastanesi\u00a0<strong>Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fum \/ Jinekolojik Onkoloji Cerrahisi Uzman\u0131 Do\u00e7. Dr. Engin \u00c7elik,<\/strong><\/strong>\u00a0\u201cTarama programlar\u0131 sayesinde rahim a\u011fz\u0131 kanserinin d\u00fcnyada ve \u00fclkemizde g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131n\u0131n giderek azald\u0131\u011f\u0131, bunun aksine rahim kanserinin ise obezite art\u0131\u015f\u0131na ba\u011fl\u0131 olarak s\u0131kl\u0131\u011f\u0131n\u0131n y\u0131llar i\u00e7erisinde artt\u0131\u011f\u0131 g\u00f6zlenmektedir\u201d diyor. \u00a0Jinekolojik kanserlerin geli\u015fiminde ilerleyen ya\u015f ve genetik yatk\u0131nl\u0131\u011f\u0131n yan\u0131 s\u0131ra ya\u015fam tarz\u0131 al\u0131\u015fkanl\u0131klar\u0131 ve \u00e7evresel fakt\u00f6rler gibi bir\u00e7ok etken rol oynayabiliyor. Risk fakt\u00f6rleri kanserin t\u00fcr\u00fcne g\u00f6re de\u011fi\u015fiklik g\u00f6steriyor. \u00d6rne\u011fin HPV (Human Papilloma Virus) rahim a\u011fz\u0131 kanserinde, obezite ise \u00f6zellikle endometrium kanserinde \u00f6ne \u00e7\u0131k\u0131yor. \u00a0<strong>Do\u00e7. Dr. Engin \u00c7elik,<\/strong>\u00a0ki\u015fisel risk de\u011ferlendirilmesinin ve uygun taramalar\u0131n yap\u0131lmas\u0131n\u0131n jinekolojik kanserlerde ya\u015famsal \u00f6nem ta\u015f\u0131d\u0131\u011f\u0131n\u0131 vurgularken, \u201cAyr\u0131ca sigara kullan\u0131m\u0131 ve k\u00f6t\u00fc beslenme al\u0131\u015fkanl\u0131\u011f\u0131 gibi hatal\u0131 al\u0131\u015fkanl\u0131klardan ka\u00e7\u0131n\u0131lmas\u0131 da son derece \u00f6nem ta\u015f\u0131maktad\u0131r\u201d diyor. \u00a0<strong>Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fum \/ Jinekolojik Onkoloji Cerrahisi Uzman\u0131 Do\u00e7. Engin \u00c7elik,\u00a0<\/strong><em><u>20 Eyl\u00fcl D\u00fcnya Jinekolojik Kanserler Fark\u0131ndal\u0131k G\u00fcn\u00fc<\/u><\/em><em>\u00a0kapsam\u0131nda<\/em><em>\u00a0<\/em><em>jinekolojik kanser riskini art\u0131ran en \u00f6nemli 4 etkeni anlatt\u0131; korunma ve erken tan\u0131ya y\u00f6nelik \u00f6nemli \u00f6nerilerde bulundu. \u00a0<\/em><\/p>\n<p><strong>HPV ENFEKS\u0130YONU \u00a0<\/strong><\/p>\n<p>HPV (Human Papilloma Virus) enfeksiyonu, \u00a0rahim a\u011fz\u0131 kanserinin en \u00f6nemli nedenini olu\u015fturuyor.\u00a0HPV\u2019nin 200 farkl\u0131 tipi bulunuyor ve \u00e7o\u011fu herhangi bir sa\u011fl\u0131k sorununa yol a\u00e7m\u0131yor. \u00a0Vir\u00fcslerin yakla\u015f\u0131k y\u00fczde 90\u2019\u0131 \u00a0genellikle herhangi bir m\u00fcdahaleye gerek kalmadan ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan 1-2 y\u0131l \u00a0i\u00e7inde temizleniyor. Ancak y\u00fcksek riskli HPV tiplerinden \u00f6zellikle HPV 16 ve HPV 18\u2019in neden oldu\u011fu kal\u0131c\u0131 enfeksiyonlar rahim a\u011fz\u0131ndaki h\u00fccrelerde y\u0131llar i\u00e7inde kansere d\u00f6n\u00fc\u015febilen de\u011fi\u015fikliklere yol a\u00e7abiliyor.<\/p>\n<p><strong>Ne yapmal\u0131? \u00a0<\/strong>Do\u00e7. Dr. Engin \u00c7elik<strong>,\u00a0<\/strong>rahim a\u011fz\u0131 kanserine kar\u015f\u0131 21 ya\u015f\u0131ndan itibaren PAP smear (rahim a\u011fz\u0131 s\u00fcr\u00fcnt\u00fcs\u00fc) testinin \u00f6nerildi\u011fini belirterek, s\u00f6zlerine \u015f\u00f6yle devam ediyor: \u201cRahim a\u011fz\u0131 kanseri taramas\u0131nda hedef, kansere d\u00f6n\u00fc\u015febilecek \u00f6nc\u00fcl lezyonlar\u0131n tespit edilmesidir. Yap\u0131lan k\u00fc\u00e7\u00fck bir operasyonla bu kanser \u00f6nc\u00fcs\u00fc lezyonlar v\u00fccuttan \u00e7\u0131kar\u0131lmaktad\u0131r. \u00dclkemizde HPV taramas\u0131n\u0131n da 30 ya\u015f\u0131ndan itibaren yap\u0131lmas\u0131 tavsiye edilmektedir. \u00a0Bunlar\u0131n yan\u0131 s\u0131ra rahim a\u011fz\u0131 kanseri a\u015f\u0131s\u0131yla bu kanser t\u00fcr\u00fc y\u00fczde 90 oran\u0131nda \u00f6nlenebilir. Kansere kar\u015f\u0131 koruyuculu\u011fun en y\u00fcksek d\u00fczeyde olmas\u0131 i\u00e7in a\u015f\u0131n\u0131n 15 ya\u015f\u0131ndan \u00f6nce yap\u0131lmas\u0131 \u00f6nem ta\u015f\u0131maktad\u0131r.\u201d \u00a0<\/p>\n<p><strong>OBEZ\u0130TE VE K\u00d6T\u00dc BESLENME<\/strong><\/p>\n<p>Obezite ve k\u00f6t\u00fc beslenme, \u00f6zellikle endometrium kanseri olmak \u00fczere jinekolojik kanser riskini artt\u0131ran \u00f6nemli fakt\u00f6rler aras\u0131nda yer al\u0131yor. \u00a0 Bunun temelinde ya\u011f dokusunun v\u00fccudun hormonal ve metabolik dengesini de\u011fi\u015ftirmesi yat\u0131yor. V\u00fccuttaki ya\u011f dokusu miktar\u0131n\u0131n artmas\u0131, \u00f6strojen d\u00fczeyinin y\u00fckselmesine ve rahim i\u00e7i tabakas\u0131ndaki h\u00fccrelerin daha fazla uyar\u0131lmas\u0131na neden olabiliyor. \u00a0Obezite ayn\u0131 zamanda ins\u00fclin direnci ve kronik inflamasyonla da ili\u015fkili. Y\u00fcksek ins\u00fclin, h\u00fccrelerin \u00e7o\u011falmas\u0131n\u0131 destekleyen mekanizmalar\u0131 etkileyebilirken, uzun s\u00fcreli inflamasyon da h\u00fccrelerin davran\u0131\u015flar\u0131n\u0131 de\u011fi\u015ftirebiliyor. \u00a0Obezitenin yan\u0131 s\u0131ra a\u015f\u0131r\u0131 \u015feker, g\u0131da katk\u0131lar\u0131 ve pestisitler gibi end\u00fcstriyel ve i\u015flenmi\u015f g\u0131dalar\u0131n \u00a0t\u00fcketiminin de jinekolojik kanser riskini art\u0131rd\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyor.\u00a0<\/p>\n<p><strong>Ne yapmal\u0131? \u00a0<\/strong>Sebze, meyve, tam tah\u0131llar, baklagiller, kuruyemi\u015fler ve zeytinya\u011f\u0131n\u0131n \u00f6n planda oldu\u011fu Akdeniz tipi beslenmeye \u00f6zen g\u00f6sterin. \u0130\u015flenmi\u015f g\u0131dalar ve a\u015f\u0131r\u0131 \u015feker t\u00fcketiminden de m\u00fcmk\u00fcn oldu\u011funca uzak durman\u0131z \u00f6nem ta\u015f\u0131yor.\u00a0<\/p>\n<p><strong>S\u0130GARA\u00a0<\/strong><\/p>\n<p>Sigara, \u00f6zellikle rahim a\u011fz\u0131 kanseri a\u00e7\u0131s\u0131ndan \u00f6nemli bir risk fakt\u00f6r\u00fc olarak kabul ediliyor. T\u00fct\u00fcn duman\u0131nda bulunan zararl\u0131 kimyasallar, \u00a0rahim a\u011fz\u0131 h\u00fccrelerinde DNA hasar\u0131na yol a\u00e7abilmenin yan\u0131 s\u0131ra Human Papilloma Vir\u00fcs\u00fc\u2019n\u00fcn ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan temizlenmesini de zorla\u015ft\u0131rarak kanser olu\u015fumuna neden olabiliyor.\u00a0<\/p>\n<p><strong>Ne yapmal\u0131?<\/strong>\u00a0Sigara kullan\u0131yorsan\u0131z mutlaka b\u0131rak\u0131n. Pasif i\u00e7icilikten de m\u00fcmk\u00fcn oldu\u011funca ka\u00e7\u0131n\u0131n.<strong>\u00a0<\/strong><\/p>\n<p><strong>GENET\u0130K ETKENLER\u00a0<\/strong><\/p>\n<p>Jinekolojik kanserin olu\u015fumunda genetik etkenlerin de rol oynad\u0131\u011f\u0131 belirtiliyor. \u00d6rne\u011fin, yumurtal\u0131k kanserlerinin en az d\u00f6rtte birinin BRCA1 ve BRCA2 gibi baz\u0131 genlerdeki kal\u0131tsal de\u011fi\u015fimler sebebiyle geli\u015fti\u011fi biliniyor.<\/p>\n<p><strong>Ne yapmal\u0131?<\/strong>\u00a0Do\u00e7. Dr. Engin \u00c7elik, \u201cJinekolojik kanserlere, \u00f6zellikle de yumurtal\u0131k kanserine kar\u015f\u0131, ailesinde ve akrabalar\u0131nda kanser hikayesi olan kad\u0131nlar\u0131n d\u00fczenli kontrollerini aksatmamalar\u0131n\u0131 ve gerekirse genetik testler yapt\u0131rarak risklerini belirlemelerini \u00f6nermekteyiz. \u00a0\u0130htiya\u00e7 halinde yak\u0131n takip ve kanser geli\u015fmeden \u00f6nleyici cerrahiler uygulamaktay\u0131z\u201d bilgisini veriyor. \u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kad\u0131n \u00fcreme organlar\u0131n\u0131 etkileyen kanserler jinekolojik kanser olarak tan\u0131mlan\u0131yor.<\/p>\n","protected":false},"author":1,"featured_media":34358,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-34357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/34357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=34357"}],"version-history":[{"count":1,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/34357\/revisions"}],"predecessor-version":[{"id":34359,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/34357\/revisions\/34359"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media\/34358"}],"wp:attachment":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=34357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=34357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=34357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}