Yeditepe \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan geli\u015ftirilen ve farkl\u0131 vir\u00fcs t\u00fcrlerine kar\u015f\u0131 y\u00fcksek etkinlik g\u00f6steren yeni bir antiviral bile\u015fik, T\u00fcrk Patent ve Marka Kurumu (T\u00dcRKPATENT) taraf\u0131ndan Alt\u0131n Madalya ile \u00f6d\u00fcllendirildi. Laboratuvar \u00e7al\u0131\u015fmalar\u0131nda d\u00f6rt farkl\u0131 vir\u00fcs modeline kar\u015f\u0131 y\u00fczde 99,99 d\u00fczeyinde antiviral etkinlik g\u00f6steren bulu\u015f, geni\u015f spektrumlu antiviral \u00fcr\u00fcnlerin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan \u00f6nemli bir potansiyel ta\u015f\u0131yor.<\/p>\n
Yeditepe \u00dcniversitesi akademisyenleri Prof. Dr. Fikrettin \u015eahin, Dr. Sevda Demir ve Ara\u015ft\u0131rma G\u00f6revlisi Bekir Can Alt\u0131ndi\u015fo\u011fullar\u0131 ile ara\u015ft\u0131rman\u0131n ba\u015flang\u0131c\u0131nda Yeditepe \u00dcniversitesi b\u00fcnyesinde g\u00f6rev yapan Prof. Dr. P\u0131nar \u015een taraf\u0131ndan geli\u015ftirilen \u201cYeni Morfolin Schiff Baz\u0131 ve Viral Patojenlerin Neden Oldu\u011fu Hastal\u0131klarda Kullan\u0131m\u0131\u201d ba\u015fl\u0131kl\u0131 bulu\u015f, T\u00dcRKPATENT Alt\u0131n Madalya \u00f6d\u00fcl\u00fcne lay\u0131k g\u00f6r\u00fcld\u00fc.<\/p>\n
Yeni sentezlenen morfolin Schiff baz\u0131 bile\u015fi\u011finin antiviral etkinli\u011fi; adenovir\u00fcs, herpes simpleks vir\u00fcs\u00fc, poliovir\u00fcs ve bovin koronavir\u00fcs\u00fc \u00fczerinde ger\u00e7ekle\u015ftirilen h\u00fccre temelli deneylerle ara\u015ft\u0131r\u0131ld\u0131. Farkl\u0131 biyolojik \u00f6zelliklere sahip bu d\u00f6rt vir\u00fcs modelinde elde edilen sonu\u00e7lar, geli\u015ftirilen bile\u015fi\u011fin geni\u015f spektrumlu antiviral uygulamalar a\u00e7\u0131s\u0131ndan umut vadeden bir aday oldu\u011funu ortaya koydu. Bulu\u015fun m\u00fcnhas\u0131r lisanslama s\u00fcrecinin de tamamlanmas\u0131, teknolojinin ticarile\u015ftirilmesi y\u00f6n\u00fcnde \u00f6nemli bir ad\u0131m olarak de\u011ferlendirildi.<\/p>\n
\u201cBilimsel Bilginin Teknolojiye ve Ekonomik De\u011fere D\u00f6n\u00fc\u015fmesi B\u00fcy\u00fck \u00d6nem Ta\u015f\u0131yor\u201d<\/strong><\/p>\n Yeditepe \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Genetik ve Biyom\u00fchendislik B\u00f6l\u00fcm Ba\u015fkan\u0131 Prof. Dr. Fikrettin \u015eahin, \u00f6d\u00fcle lay\u0131k g\u00f6r\u00fclen bulu\u015fun farkl\u0131 disiplinlerden ara\u015ft\u0131rmac\u0131lar\u0131n ortak \u00e7al\u0131\u015fmas\u0131n\u0131n bir \u00fcr\u00fcn\u00fc oldu\u011funu belirterek \u00fcniversitelerde \u00fcretilen bilimsel bilginin teknolojiye d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinin \u00f6nemine dikkat \u00e7ekti.<\/p>\n Bilimsel ara\u015ft\u0131rmalar\u0131n yaln\u0131zca akademik yay\u0131nlarla s\u0131n\u0131rl\u0131 kalmamas\u0131 gerekti\u011fini vurgulayan \u015eahin, \u00fcniversitelerin bilgi \u00fcretmenin yan\u0131 s\u0131ra toplumsal ve ekonomik de\u011fer olu\u015fturan yenilik\u00e7i teknolojilerin geli\u015ftirilmesinde de \u00f6nc\u00fc rol \u00fcstlenmesi gerekti\u011fini ifade etti.<\/p>\n T\u00fcrkiye\u2019de son y\u0131llarda yenilik\u00e7i \u00fcr\u00fcn ve teknolojilerin geli\u015ftirilmesi ile patentlenmesi konusunda \u00f6nemli ilerlemeler kaydedildi\u011fini belirten \u015eahin, bu ba\u015far\u0131lar\u0131n s\u00fcrd\u00fcr\u00fclebilir ekonomik de\u011fere d\u00f6n\u00fc\u015fmesinde ticarile\u015ftirme s\u00fcre\u00e7lerinin kritik \u00f6neme sahip oldu\u011funu s\u00f6yledi.<\/p>\n \u015eahin, \u00fcniversite-sanayi i\u015f birli\u011finin g\u00fc\u00e7lendirilmesi, patentli bulu\u015flar\u0131n lisanslama ve teknoloji transferi yoluyla sanayiye kazand\u0131r\u0131lmas\u0131 ve geli\u015ftirilen yenilik\u00e7i \u00fcr\u00fcnlerin uluslararas\u0131 pazarlara ta\u015f\u0131nmas\u0131n\u0131n T\u00fcrkiye\u2019nin teknoloji geli\u015ftirme kapasitesine \u00f6nemli katk\u0131lar sa\u011flayaca\u011f\u0131n\u0131 vurgulad\u0131.<\/p>\n Pandemi Sonras\u0131 Antiviral Ara\u015ft\u0131rmalara Odakland\u0131lar<\/strong><\/p>\n Bulu\u015fun kimyasal altyap\u0131s\u0131n\u0131 geli\u015ftiren Prof. Dr. P\u0131nar \u015een, G\u00fcney Afrika\u2019daki Rhodes \u00dcniversitesi\u2019nde y\u00fcr\u00fctt\u00fc\u011f\u00fc doktora sonras\u0131 ara\u015ft\u0131rmalar\u0131nda antikanser ve antibakteriyel bile\u015fikler \u00fczerine \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n COVID-19 pandemisinin ard\u0131ndan antiviral ara\u015ft\u0131rmalar\u0131n \u00f6neminin daha da belirginle\u015fti\u011fini ifade eden \u015een, farkl\u0131 vir\u00fcs t\u00fcrlerine kar\u015f\u0131 etkili olabilecek yeni molek\u00fcller geli\u015ftirmek amac\u0131yla kimya ve nanoteknolojiyi bir araya getiren bir yakla\u015f\u0131m benimsediklerini anlatt\u0131.<\/p>\n Organik kimya, inorganik kimya ve malzeme bilimini i\u00e7erecek \u015fekilde sentetik kimya alan\u0131nda \u00e7al\u0131\u015fan Prof. Dr. \u015een, yeni bir molek\u00fcl\u00fcn laboratuvar ko\u015fullar\u0131nda biyolojik etkinlik g\u00f6stermesinin tek ba\u015f\u0131na yeterli olmad\u0131\u011f\u0131n\u0131 belirterek, geli\u015ftirilen bile\u015fi\u011fin etkinli\u011fini art\u0131rmak amac\u0131yla nanoteknolojik yakla\u015f\u0131mlardan yararland\u0131klar\u0131n\u0131 ifade etti.<\/p>\n \u015een, elde etti\u011fi form\u00fclasyonun farkl\u0131 vir\u00fcs gruplar\u0131na kar\u015f\u0131 g\u00f6sterdi\u011fi etkinli\u011fin, geni\u015f spektrumlu antiviral teknolojilerin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan \u00f6nemli bir ba\u015flang\u0131\u00e7 olu\u015fturdu\u011funu s\u00f6yledi.<\/p>\n D\u00f6rt Farkl\u0131 Vir\u00fcs Modelinde G\u00fc\u00e7l\u00fc Antiviral Etkinlik<\/strong><\/p>\n Ara\u015ft\u0131rman\u0131n deneysel sonu\u00e7lar\u0131n\u0131 de\u011ferlendiren Ara\u015ft\u0131rma G\u00f6revlisi Bekir Can Alt\u0131ndi\u015fo\u011fullar\u0131, \u00e7al\u0131\u015fmada biyolojik yap\u0131lar\u0131 ve \u00f6zellikleri birbirinden farkl\u0131 d\u00f6rt vir\u00fcs modelinin kullan\u0131ld\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n Adenovir\u00fcs, herpes simpleks vir\u00fcs\u00fc, poliovir\u00fcs ve bovin koronavir\u00fcs\u00fc \u00fczerinde ger\u00e7ekle\u015ftirilen laboratuvar deneylerinde y\u00fczde 99,99 d\u00fczeyinde antiviral etkinlik g\u00f6zlemlediklerini ifade eden Alt\u0131ndi\u015fo\u011fullar\u0131, farkl\u0131 vir\u00fcs gruplar\u0131na kar\u015f\u0131 etkili olabilecek antiviral malzemelerin geli\u015ftirilmesinin ara\u015ft\u0131rman\u0131n temel hedeflerinden biri oldu\u011funu s\u00f6yledi.<\/p>\n COVID-19 pandemisinin viral enfeksiyonlar\u0131n yaln\u0131zca insan sa\u011fl\u0131\u011f\u0131 \u00fczerinde de\u011fil, sosyal ya\u015fam ve k\u00fcresel ekonomi \u00fczerinde de ciddi etkiler olu\u015fturabilece\u011fini g\u00f6sterdi\u011fini belirten Alt\u0131ndi\u015fo\u011fullar\u0131, gelecekte ortaya \u00e7\u0131kabilecek viral salg\u0131nlara haz\u0131rl\u0131kl\u0131 olunabilmesi i\u00e7in geni\u015f etki spektrumuna sahip yeni antiviral teknolojilere ihtiya\u00e7 duyuldu\u011funu vurgulad\u0131.<\/p>\n \u201cBulgular Umut Verici, Ancak \u0130leri Ara\u015ft\u0131rmalar Gerekiyor\u201d<\/strong><\/p>\n \u00c7al\u0131\u015fman\u0131n biyolojik de\u011ferlendirmelerini ger\u00e7ekle\u015ftiren Dr. Sevda Demir, ara\u015ft\u0131rman\u0131n en dikkat \u00e7ekici y\u00f6nlerinden birinin hem DNA hem de RNA vir\u00fcslerini, ayr\u0131ca zarfl\u0131 ve zarfs\u0131z vir\u00fcs modellerini kapsamas\u0131 oldu\u011funu belirtti.<\/p>\n Geli\u015ftirilen bile\u015fi\u011fin farkl\u0131 vir\u00fcs gruplar\u0131nda y\u00fcksek antiviral etkinlik g\u00f6stermesinin bilimsel a\u00e7\u0131dan \u00f6nemli oldu\u011funu ifade eden Demir, mevcut sonu\u00e7lar\u0131n h\u00fccre temelli laboratuvar deneylerinden elde edildi\u011fine dikkat \u00e7ekti.<\/p>\n Demir, bu bulgular\u0131n do\u011frudan klinik kullan\u0131ma haz\u0131r bir tedavi geli\u015ftirildi\u011fi anlam\u0131na gelmedi\u011fini vurgulayarak sonraki a\u015famalarda bile\u015fi\u011fin antiviral etki mekanizmas\u0131n\u0131n ayr\u0131nt\u0131l\u0131 bi\u00e7imde ara\u015ft\u0131r\u0131laca\u011f\u0131n\u0131 ve laboratuvar ortam\u0131nda elde edilen sonu\u00e7lar\u0131n canl\u0131 sistemlerde de do\u011frulanmas\u0131n\u0131n hedeflendi\u011fini s\u00f6yledi.<\/p>\n Ara\u015ft\u0131rman\u0131n insan sa\u011fl\u0131\u011f\u0131n\u0131n yan\u0131 s\u0131ra veteriner hekimlik alan\u0131nda da potansiyel uygulamalar ta\u015f\u0131d\u0131\u011f\u0131n\u0131 belirten Demir, \u00f6zellikle s\u0131\u011f\u0131rlarda hastal\u0131klara neden olabilen bovin koronavir\u00fcs\u00fcne kar\u015f\u0131 elde edilen sonu\u00e7lar\u0131n hayvan sa\u011fl\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan da de\u011ferlendirilmesi gerekti\u011fini ifade etti.<\/p>\n Hedef: Patentli Bulu\u015fun Yenilik\u00e7i Antiviral \u00dcr\u00fcnlere D\u00f6n\u00fc\u015ft\u00fcr\u00fclmesi<\/strong><\/p>\n T\u00dcRKPATENT Alt\u0131n Madalya \u00f6d\u00fcl\u00fcyle bilimsel ve teknolojik a\u00e7\u0131dan \u00f6nemli bir ba\u015far\u0131 elde eden ara\u015ft\u0131rma ekibi, bundan sonraki s\u00fcre\u00e7te geli\u015ftirilen bile\u015fi\u011fin etki mekanizmas\u0131n\u0131n ayd\u0131nlat\u0131lmas\u0131, etkinlik ve g\u00fcvenlilik \u00e7al\u0131\u015fmalar\u0131n\u0131n ilerletilmesi ve uygun kullan\u0131m alanlar\u0131n\u0131n belirlenmesi \u00fczerine odaklanmay\u0131 hedefliyor.<\/p>\n Bulu\u015fun m\u00fcnhas\u0131r lisanslama s\u00fcrecinin ger\u00e7ekle\u015ftirilmi\u015f olmas\u0131, \u00fcniversite b\u00fcnyesinde geli\u015ftirilen bilimsel bilginin sanayiye aktar\u0131lmas\u0131 ve katma de\u011feri y\u00fcksek yenilik\u00e7i antiviral \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesi a\u00e7\u0131s\u0131ndan \u00f6nemli bir geli\u015fme olarak \u00f6ne \u00e7\u0131k\u0131yor.<\/p>\n Yeditepe \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n elde etti\u011fi bu ba\u015far\u0131, disiplinler aras\u0131 bilimsel i\u015f birli\u011finin, patent odakl\u0131 ara\u015ft\u0131rma yakla\u015f\u0131m\u0131n\u0131n ve \u00fcniversite-sanayi etkile\u015fiminin yenilik\u00e7i sa\u011fl\u0131k teknolojilerinin geli\u015ftirilmesindeki \u00f6nemini bir kez daha ortaya koyuyor.<\/p>\n \u00a0<\/p>\n \u00a0<\/p>\n Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":" Yeditepe \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan geli\u015ftirilen ve farkl\u0131 vir\u00fcs t\u00fcrlerine kar\u015f\u0131 y\u00fcksek etkinlik g\u00f6steren yeni bir antiviral bile\u015fik, T\u00fcrk Patent ve Marka Kurumu (T\u00dcRKPATENT) taraf\u0131ndan Alt\u0131n Madalya ile \u00f6d\u00fcllendirildi.<\/p>\n","protected":false},"author":1,"featured_media":40928,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-40927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-egitim"],"_links":{"self":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/40927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=40927"}],"version-history":[{"count":1,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/40927\/revisions"}],"predecessor-version":[{"id":40929,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/40927\/revisions\/40929"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media\/40928"}],"wp:attachment":[{"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=40927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=40927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akdenizolay.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=40927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}